Gestate SR 200 Tablet contains Progesterone (Natural Micronized) 200 mg, a hormone essential for the regulation of the menstrual cycle and maintenance of pregnancy. This sustained-release formulation ensures a gradual and consistent release of progesterone, optimizing therapeutic efficacy and minimizing fluctuations in hormone levels. Progesterone plays a critical role in preparing the endometrium for implantation of the fertilized ovum and supports early pregnancy by maintaining the uterine lining. Gestate SR 200 is indicated for the treatment of progesterone deficiency conditions, including luteal phase support in assisted reproductive technology (ART) cycles, prevention of threatened miscarriage, and management of amenorrhea due to hormonal imbalance. It may also be used in hormone replacement therapy (HRT) in postmenopausal women to counteract the effects of estrogen on the endometrium. The natural micronized form enhances bioavailability and tolerability. Administration should be as prescribed by a healthcare professional, with dosage tailored to individual patient needs. Common side effects may include mild gastrointestinal discomfort, headache, and breast tenderness. Contraindications include known hypersensitivity to progesterone, unexplained vaginal bleeding, and active thromboembolic disorders. Regular monitoring is advised to ensure therapeutic outcomes and detect any adverse reactions promptly.