Genflam-SP 50mg/325mg/10mg Tablet is a combination analgesic and anti-inflammatory medication containing Diclofenac sodium 50mg, Paracetamol 325mg, and Serratiopeptidase 10mg. Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol provides analgesic and antipyretic action through central inhibition of prostaglandin synthesis, complementing Diclofenac’s peripheral effects. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation. This combination is indicated for the management of acute and chronic musculoskeletal pain, postoperative pain, inflammatory conditions such as arthritis, and soft tissue injuries. Genflam-SP offers rapid and sustained relief from pain and inflammation while reducing swelling and enhancing tissue healing. It is typically administered orally, with dosage and duration tailored to the severity of symptoms and patient response. Caution is advised in patients with gastrointestinal ulcers, renal or hepatic impairment, and hypersensitivity to NSAIDs. Concomitant use with other NSAIDs or anticoagulants should be avoided. Regular monitoring is recommended during prolonged therapy to minimize adverse effects.