Genericart Amlodipine+Lisinopril 5mg/5mg Tablet is a combination antihypertensive medication containing Amlodipine 5mg and Lisinopril 5mg. Amlodipine, a dihydropyridine calcium channel blocker, acts by inhibiting calcium ion influx into vascular smooth muscle and cardiac muscle, resulting in vasodilation and reduced peripheral vascular resistance. Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, lowers blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and decreasing aldosterone secretion. This dual mechanism effectively manages hypertension, reducing the risk of cardiovascular events such as stroke, myocardial infarction, and heart failure. The combination is particularly beneficial for patients inadequately controlled on monotherapy or those requiring multiple agents to achieve target blood pressure. Genericart Amlodipine+Lisinopril is administered orally, typically once daily, with dosage adjustments based on therapeutic response and tolerability. Common adverse effects may include dizziness, hypotension, cough, and peripheral edema. Contraindications include a history of angioedema related to ACE inhibitors, pregnancy, and severe renal impairment. Regular monitoring of blood pressure, renal function, and electrolytes is recommended during therapy to ensure safety and efficacy. This combination offers a convenient and effective option for long-term hypertension management.