ENPM Tablet is a combination pharmaceutical formulation containing Pregabalin 75 mg, Nortriptyline 10 mg, and Methylcobalamin 1500 mcg, indicated primarily for the management of neuropathic pain and associated neurological disorders. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, exerts its therapeutic effect by modulating calcium channels in the central nervous system, thereby reducing neuronal excitability and alleviating neuropathic pain. Nortriptyline, a tricyclic antidepressant, enhances pain relief through inhibition of norepinephrine and serotonin reuptake, contributing to improved mood and analgesia. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, promoting recovery in peripheral neuropathies. The synergistic action of these three components provides comprehensive management of chronic neuropathic conditions, including diabetic neuropathy, postherpetic neuralgia, and other nerve injury-related pain syndromes. ENPM Tablet is typically administered orally as per physician’s prescription, with dosage tailored to individual patient needs and clinical response. Caution is advised in patients with renal impairment, cardiovascular disorders, or a history of hypersensitivity to any component. Adverse effects may include dizziness, dry mouth, sedation, and gastrointestinal disturbances. Regular monitoring and adherence to prescribed dosage ensure optimal therapeutic outcomes with minimal side effects.